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Vascular diseases from an clinical and research perspective

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Merging expertise, the key to boost the clinical outcome in aneurysm treatment
Whether EVAR is useful for the individual patient with an AAA or whether this technique is considered to be a failed experiment is being discussed by respected clinicians and technicians with great passion and even fire. The various guidelines seem to be at odds with each other and also benchtop testing and clinical outcomes are often conflicting. Based on that, what should the clinician say when the patient asks, 'what would you do in my situation, doc’? This theme session sheds light on the future of EVAR from a historical perspective. Will you know what your advice would be to the AAA patient at the end of this session?

The programme

14.00 - 14.10

Welcome & Introduction
Prof.dr. Bob Geelkerken - University of Twente & Medisch Spectrum Twente 

14.10 - 14.30

The patient perspective
Is endovascular aortic aneurysm treatment a failed experiment or a blessing to the patient
Matt Thompson - Endologix

14.35 - 14.50

14.50 - 15.05

The manufacturer perspective
...On Thrombogenicity
Dr. Robbie Brodie - Terumo Aortic

...On exoskeleton
Simon Overeem - Medtronic

15.10 - 15.25

15.25 - 15.40

Future perspectives  in the aortic dynamics 
Pulsatility and expansion; friend or enemy of sustainability
Jaimy Simmering MSc - University of Twente & Medisch Spectrum Twente 

Desired and unwanted blood-vesselwall-graft interaction
Prof.dr. Michel Reijnen

15.40 - 16.00

Panel discussion
Moderated by Erik Groot Jebbink & Bob Geelkerken - University of Twente
Panel members: Prof.dr. Michel Versluis, Prof.dr. Michel Reijnen, Simon Overeem

The speakers

  • Prof.dr. Michel Reijnen

    Prof.dr. Michel Reijnen

    • Multi-Modality Medical Imaging Group, UTwente and Dept. of Surgery, Rijnstate
    • Professor and Vascular Surgeon

    Desired and unwanted blood-vesselwall-graft interaction
    Assessment of vascular flow patterns is clinically important as they are related to progression of various vascular diseases and also to failure modes of endovascular treatment, through mechanisms such as recirculating flow and low wall shear stress. Imaging of vascular flow patterns is technically demanding, due to the often complex flow patterns. In vitro, flow 2D flow can reliably be assessed using laser-based Particle Image Velocimetry (LaserPIV), but accurate blood flow quantification is not yet used in clinical practice, while several techniques have been developed. These techniques might impact clinical decision making and improve the outcomes of interventions. These techniques include novel ultrasound based methods (echoPIV), Phase-Contrast Magnetic Resonance Imaging (PC-MRI) and Computational Fluid dynamics (CFD), with all having their pro’s and con’s.

    Michel Reijnen completed his (endo)vascular training in January 2004 and joined the Rijnstate Hospital in Arnhem as staff vascular surgeon in 2007, where he works in a team of 5 vascular surgeons and 5 interventional radiologists. He is involved in multiple trials in the endovascular area and initiator and principal investigator of various (inter)national multicenter randomized trials and Registries. Michel Reijnen is professor ‘Endovascular Imaging and Innovation’, at the Multi-Modality Medical Imaging group of the University of Twente, Enschede. He has published over 250 peer reviewed manuscripts and book chapters and is reviewer of several journals and a regular faculty member of several international symposia. As the course director of surgical residents until 2017 and, having organized multiple workshops in the endovascular field, he has a profound interest and experience in surgical training.

  • Jaimy Simmering MSc

    Jaimy Simmering MSc

    • PhD candidate
    • MultiModality Medical Imaging M3i group, University of Twente and Department of Surgery, Medisch Spectrum Twente

    Pulsatility and expansion; friend or enemy of sustainability
    Since the development of endovascular aorta repair (EVAR) in the late 80’s, it has become the standard treatment of abdominal aortic aneurysms. Though successful in most cases, patients may still develop complications during follow-up. This may have something to do with the fact that the aorta and endoprostheses are challenged over 30.000.000 times a year by the cardiac pulsatility induced blood pressure wave and a single point on the aorta may travel from Enschede to Madagascar in 10 years. With our study into Aorta dynamics after endovascular aorta repair (ADEAR) we are gaining more and more insight in these phenomena. Together we will walk through the past and future perspectives of aorta dynamics.

    Jaimy Simmering is born and raised in Twente and started the study Technical Medicine in 2012 in Twente as well. During her graduation internship she investigated dynamics of an endoprosthesis for abdominal aortic aneurysms at the Department of (Vascular) Surgery in the Medisch Spectrum Twente (MST) hospital and the MultiModality Medical Imaging (M3i) group at the University of Twente. After her graduation this research project still had a lot of interesting opportunities, so she continued working on the project as a PhD candidate. Now it is almost 3 years later and more insights have been gained about the dynamics of endoprostheses, though there still is a lot to learn.

  • Dr. Robbie Brodie

    Dr. Robbie Brodie

    • Global R&D Manager - Global Technology Team
    • Terumo Aortic

    The Manufacturer Perspective on Thrombogenicity
    Terumo Aortic are a global manufactures of vascular prostheses. These vascular implants must be designed for long-term in-vivo safety and efficacy, including long-term patency in the blood flow environment. To achieve this, consideration must be given during the design process to the post-implant flow haemodynamics. This presentation will look at some of the techniques currently employed at Terumo Aortic to achieve this, together with current research activities to improve these design capabilities.

    Dr Robbie Brodie is Global R&D Manager of the Global Technology Team at Terumo Aortic, who design and manufacture vascular prosthesis products for surgical treatment of aortic diseases. His R&D team, based in both Glasgow, Scotland and Sunrise, Florida, are responsible for mechanical design, analysis and testing to ensure the long-term durability of vascular prostheses in-vivo. During his 12 years at the company, Robbie has led development of new durability analysis and testing capabilities at the company in collaboration with university partners, and in 2018 was awarded a PhD for his work with University of Strathclyde on stent material characterisation. Over the past 5 years he has acted as industrial supervisor on a number of very successful collaboration projects with University of Twente in the Netherlands, led by Professor Geelkerken.

  • Prof.dr. Bob Geelkerken

    Prof.dr. Bob Geelkerken

    • Clinical professor and Consultant Vascular Surgery
    • Modality Medical Imaging group, Techmed Centre, University of Twente & Medisch Spectrum Twente

    What’s the problem?
    The importance of working together to improve the outcome for the target group, the patient with aortic aneurysmal disease , will be outlined with a number of appealing examples.

    Bob Geelkerken started his surgical career at the Leiden University in 1986. Since 1995 he is appointed as a consultant vascular surgeon at Medisch Spectrum Twente. In 1996 he defended his thesis "Ischemic disorders of the splanchnic circulation.In 2016 Bob was appointed as clinical professor at the predecessor of the M3i group. The focus of his research is on "aortic dynamics" and 'tissue perfusion' and mesenteric ischemia.

General information
  • When: November 3 
  • Time: 14.00 - 16.00
  • How: Live & Digital
  • For whom: All attendees
  • Host: Prof.dr. Bob Geelkerken